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2D-IR Spectroscopy
25 Oct 2024
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The correlation of one laser excitation frequency with another is known as multidimensional spectroscopy, and on ultrafast timescales is the optical analogue of multidimensional nuclear magnetic resonance spectroscopy. Applied to the vibrational degrees of freedom of a molecule, multidimensional spectroscopy gives a class of techniques starting with two-dimensional infrared (2D-IR) spectroscopy. 

​Applications

Examples of questions addressable by 2D-IR include:

  • how long is water’s H-bond memory?
  • are protein binding sites dynamic on ultrafast timescales?
  • can we detect non-bonded interactions of a drug in a protein binding site?
  • what is the connectivity and interactions of different functional groups in a molecular system?
  • how dynamic is the solvent around a molecule?

Selected publications

See the following papers for applications of 2D-IR:

  • Detection of paracetamol binding to albumin in blood serum using 2D-IR spectroscopy
  • 2D-Infrared Spectroscopy of Proteins in Water: Using the Solvent Thermal Response as an Internal Standard​



Contact: Greetham, Greg (STFC,RAL,CLF)

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