CLF News Bite: Observing Interactions between 4 Stranded DNA and the “Light-Switch” Complex
07 Sep 2020
- Helen Towrie







​Published in Chemical Communications: The Ultra team in collaboration with University College Dublin used time-resolved infrared spectroscopy to understand how the ruthenium light-switch complex binds to i-motif DNA.​

I-motif DNA (also known as i-DNA) is a peculiar 4 stranded DNA, unlike the iconic double stranded DNA most of us know. I-motif DNA plays a part in cell production, and the team were keen to learn more about this structure by observing the interaction it has with the ruthenium “light-switch" complex ([Ru(phen)2dppz]2+) – particularly how the loops in the complex may influence its binding to i-motif DNA.

Read the abstract here!

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Contact: Towrie, Helen (STFC,RAL,CLF)