Single molecule tracking of bio-molecules to study cellular processes in three-dimensions, Forster Resonance Energy Transfer as a tool for measuring intermolecular distances and super-resolution microscopy of cell and tissue samples. Quantitative analysis of fluorescence microscopy datasets to extract biologically relevant information.
Chris' biological interests lie in investigating how signal transduction by the Epidermal Growth Factor Receptor family of tyrosine kinase receptors is regulated by their conformation, their interactions with each other and also with constituents of the cell membrane and cytoplasmic molecules. Studying the relationship between deregulation of these signals and disease (e.g. cancer) and elucidating the effects of therapeutic drugs targeted to these receptors at the molecular level.
PhD, University of Liverpool. ‘A quantitative Förster resonance energy transfer method reveals functionally relevant structural variations in ErbB transmembrane receptors in cells’.
Chris has been a member of the LSF since 2008 and is currently an OCTOPUS facility Link Scientist.