Marisa Martin-Fernandez publications
20 Nov 2019
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List of publicati​ons​

Bateman, B. C., Zanetti-Domingues, L. C., Moores, A. N., Needham, S. R., Rolfe, D. J., Wang, L., Clarke, D. T. and Martin-Fernandez, M. L. (2019). Super-resolution Microscopy at Cryogenic Temperatures Using Solid Immersion Lenses. Bio-protocol 9(22): e3426. DOI: 10.21769/BioProtoc.3426.

Marisa L. Martin-Fernandez, David T. Clarke, Selene K. Roberts, Laura C. Zanetti-Domingues and Francesco L. Gervasio. Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer. Cells 2019, 8(4), 316; https://doi.org/10.3390/cells8040316

Ahmed Elbediwy, Yixiao Zhang, Mathias Cobbaut, Philippe Riou, Ray S. Tan, Selene K. Roberts, Chris Tynan, Roger George, Svend Kjaer, Marisa L. Martin-Fernandez, Barry J. Thompson, Neil Q. McDonald, Peter J. Parker. The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity. J Cell Sci 2019 132: jcs223743 doi: 10.1242/jcs.223743

Michael Hirsch, Richard Wareham, Ji W. Yoon, Daniel J. Rolfe, Laura C. Zanetti-Domingues, Michael P. Hobson, Peter J. Parker, Marisa L. Martin-Fernandez, Sumeetpal S. Singh. A global sampler of single particle tracking solutions for single molecule microscopy. PLOS ONE October 2019, 10.1371/journal.pone.0221865​.

Javier Periz, Mario Del Rosario, Alexandra McStea, Simon Gras, Colin Loney, Lin Wang, Marisa L. Martin-Fernandez & Markus Meissner. ​​A highly dynamic F-actin network regulates transport and recycling of micronemes in Toxoplasma gondii vacuoles. Nature Communications 10(1) 2019, DOI: 10.1038/s41467-019-12136-2​.

J. F. McKenna, D. J. Rolfe, S. E. D. Webb, A. F. Tolmie, S. W. Botchway, M. L. Martin-Fernandez, C. Hawes, and J. Runions. The cell wall regulates dynamics and size of plasma-membrane nanodomains in Arabidopsis. PNAS (2019) 116 (26) 12857-12862.

David T. Clarke and Marisa L. Martin-Fernandez. A Brief History of Single-Particle Tracking of the Epidermal Growth Factor Receptor. Methods and Pr​otocols (2019)​ DOI: 10.3390/mps2010012.

Lin Wang, Benji Bateman, Laura C. Zanetti-Domingues, Amy N. Moores, Sam Astbury, Christopher Spindloe, Michele C. Darrow, Maria Romano, Sarah R. Needham, Konstantinos Beis, Daniel J. Rolfe, David T. Clarke & Marisa L. Martin-Fernandez.​ Solid immersion​​​ microscopy images cells under cryogenic conditions with 12 nm resolution. Nature Communications Biology (2019) Volume 2, Article number: 74.

Selene K. Roberts, Michael Hirsch, Alexandra McStea, Laura C. Zanetti-Domingues, Jeroen Claus, Peter J. Parker, Lin Wang, and Marisa L. Martin-Fernandez. Cluster analysis of endogenous HER2 and HER3 receptors in SKBR3 cells. Bio-protocol (2018). DOI: 10.21769/BioProtoc.3096.

Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M.P. van Bergen en Henegouwen, George Santis, Andrew H.A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, and Marisa L. Martin-Fernandez. The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers. Nat Comms (2018) DOI:10.1038/s41467-018-06632-0.

J. Claus, G. Patel, F. Autore, A. Colomba, Gregory Weitsman, Fanya N Soliman,  Selene Roberts, Laura C Zanetti-Domingues, Michael Hirsch, Francesca Collu, Roger George, Elena Ortiz-Zapater, Paul R Barber, Boris Vojnovic, Yosef Yarden, Marisa L Martin-Fernandez,   Angus Cameron,  Franca Fraternali, Tony Ng  and Peter J Parker. Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface. eLife (2018);7:e32271 doi: 10.7554/eLife.32271

Tiede C., Bedford R., Heseltine S.J., Smith G., Wijetunga I., Ross R., AlQallaf D., Roberts A.P., Balls A., Curd A., Hughes R.E, Martin H., Needham S.R., Zanetti-Domingues L.C., Sadigh Y., Peacock T.P., Tang A.A., Gibson N., Kyle H., Platt G.W., Ingram N., Taylor T., Coletta L.P., Manfield I., Knowles M., Bell S., Esteves F., Maqbool A., Prasad R.K, Drinkhill M., Bon R.S., Patel V., Goodchild S.A., Martin-Fernandez M.L., Owens R.J., Nettleship J.E., Webb M.E., Harrison M., Lippiat J.D., Ponnambalam S., Peckham M., Smith A., Ferrigno P.K., Johnson M., McPherson M.J., Tomlinson D.C. Affimer proteins are versatile and renewable affinity reagents. eLife (2017) DOI: 10.7554/eLife.24903

Needham, S.R., Roberts, S.K., Arkhipov, A., Mysore, V.P., Tynan, C.J., Zanetti-Domingues, L.C., Kim, E.T, Losasso, V., Korovesis, D., Hirsch, M., Rolfe, D.J., Clarke, D.T., Winn, M., Lajevardipour, A., Clayton, A.H.A. Pike, L.J., Perani, M., Parker, P.J., Shan, Y, Shaw, D.E. & Martin-Fernandez, M.L. EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.  Nat Comms (2016) DOI: 10.1038/ncomms13307

Coles, B.C., Webb, S.E.D., Schwartz, N., Rolfe, D.J. Martin-Fernandez, M.L., and Valentina Lo Schiavo. Characterisation of the effects of optical aberrations in single molecule techniques. Biomed. Opt. Express. (2016) DOI:10.1364/BOE.7.001755

Christopher J. Tynan, Valentina Lo Schiavo, Laura Zanetti-Domingues, Sarah R. Needham, Selene K. Roberts, Michael Hirsh, Daniel J. Rolfe, Dimitrios Korovesis, David T. Clarke and Marisa L. Martin-Fernandez.  A tale of the epidermal growth factor receptor: The quest for structural resolution on cells. Methods. (2015) DOI: 10.1016/j.ymeth.2015.10.009

Stephen E D Webb, Michael Hirsch, Sarah R Needham, Benji  C Coles, Selene K Roberts, Laura C Zanetti-Domingues, Chris J Tynan, Marisa L. Martin-Fernandez and Daniel J Rolfe. Nanometric molecular separation measurements by single molecule photobleaching. Methods (2015) DOI: 10.1016/j.ymeth.2015.05.009)

​Laura C. Zanetti-Domingues, Michael Hirsch, Christopher J. Tynan, Daniel J. Rolfe, Teodor Boyadzhiev, Kathrin Scherer, David T. Clarke, Marisa L. Martin-Fernandez, and Sarah R. Needham. Determining the geometry of oligomers of the human epidermal growth factor family on cells with 7 nm resolution. Progress in Biophys & Mol Biol. (2015) doi:10.1016/j.pbiomolbio.2015.04.002

O. Coban, L. Zanetti-Dominguez, D. R. Matthews, D. J. Rolfe, G. Weitsman, P.R. Barber, J. Barbeau, V. Devauges, F. Kampmeier, M. Winn, Bo. Vojnovic, P. J. Parker, K. A. Lidke, D. S Lidke, S. M. Ameer-Beg, M. Martin-Fernandez and T. Ng. Effect of phosphorylation on the EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM. Biophys. J. (2015), 108 (5), 1013-1026. DOI: 10.1016/j.bpj.2015.01.005

Sarah R. Needham, Laura C. Zanetti-Domingues, Kathrin Scherer, Michael Hirsch, Daniel J. Rolfe, Selene K. Roberts, Marisa L. Martin-Fernandez, David T. Clarke, Christopher J. Tynan. Determining the geometry of oligomers of the human epidermal growth factor family on cells with <10 nm resolution. Biochem. Soc. Trans. (2015) (3):309-14. doi: 10.1042/BST20140318.

T. Kiuchi, E. Ortiz-Zapater, J. Monypenny, D. R. Matthews, J. Barbeau, O. Coban, K. Lawler, B. Burford, D. Rolfe, E. de Rinaldis, D. Dafou, M. A. Simpson, N. Woodman, S. Pinder, C.E. Gillett, V. Devauges, S. P. Poland, G. Fruhwirth, P. Marra, Y. L. Boersma, A. Plückthun, W.J Gullick, Y. Yarden, G.Santis, M. Winn, M. Martin-Fernandez, P. Parker, A. Tutt, S. M. Ameer-Beg, Tony Ng. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility. Sci. Signal. (2014) Vol. 7, Issue 339, p. ra78 DOI: 10.1126/scisignal.2005157

Needham, S.R; Zanetti-Domingues, L.C; Hirsch, M., Rolfe, D. J; Tynan, C.J; Roberts, S K; Martin-Fernandez, M.L; Clarke, David T. Structure-function relationships and supramolecular organization of the EGFR (epidermal growth factor receptor) on the cell surface. Biochem. Soc. Trans. (2014) 42 Issue:1: 114-9 DOI:10.1042/BST20130236

Oana C. Coban, Daniel R. Matthews, Simon Ameer-Beg, Daniel J. Rolfe, Gregory Weitsman, Florian Kampmeier, Martyn Winn, Laura Zanetti-Domingues, Marisa L. Martin-Fernandez, Tony Ng. Modulation of EGFR Dimer Stability by Manipulation of Phosphorylation in Situ. Biophys. J. (2014) 106 (2) p101a (doi: http://dx.doi.org/10.1016/j.bpj.2013.11.628)

Laura C. Zanetti-Domingues., Christopher J. Tynan., Daniel J. Rolfe, David T. Clarke, Marisa L. Martin-Fernandez. Hydrophobic Fluorescent Probes Introduce Artifacts into Single Molecule Tracking Experiments Due to Non-Specific Binding. PLoS One (2013) DOI: 10.1371/journal.pone.0074200.

M.L. Martin-Fernandez, C.J. Tynan & S.E.D. Webb. A 'Pocket Guide' to Total Internal Reflection Fluorescence. J. Microscopy. (2013) 252(1):16-22 doi: 10.1111/jmi.12070.

Zanetti-Domingues, L.C., Martin-Fernandez, M.L., Needham S.R, D.J Rolfe and D.T. Clarke. A systematic investigation of differential effects of cell culture substrates on the extent of artifacts in single-molecule tracking. PLoS ONE(2013) 7(9): e45655. doi:10.1371/journal.pone.0045655.

S. R. Needham, M. Hirsch, D.J. Rolfe, D. T Clarke, L. C Zanetti-Domingues, R. Wareham, and M.L Martin-Fernandez. Measuring EGFR separations on cells with ~10 nm resolution via fluorophore localization imaging with photobleaching. PLoS ONE(2013) 8(5):doi:0.1371/journal.pone.0062331

Hirsch, M, Wareham RJ, Martin-Fernandez ML, Hobson MP and Rolfe DJ. A Stochastic Model for Electron Multiplication Charge-Coupled Devices – From Theory to Practice. PLoS ONE(2013) 8(1): e53671. doi:10.1371/journal.pone.0053671.

L.C. Zanetti-Domingues, S.E.D. Webb, C. J. Tynan, D. J. Rolfe, M. Hirsch, B. Coles, S.R. Needham,  S. K. Roberts, D.T. Clarke and M. L. Martin-Fernandez. Simultaneous, multicolour single molecule imaging of the entire human epidermal growth factor receptor (HER) family in live breast cancer cells. Annals of Oncology (2012) doi.org/10.1093/annonc/mdt086.3.

M.L. Martin-Fernandez and David T. Clarke. Single Molecule Fluorescence Detection and Tracking in Mammalian Cells: The State-of-the-Art and Future Perspectives. Special Issue "Advances in Single Molecule Spectroscopy" - Int. J. Mol. Sci.(2012) doi:10.3390/ijms131114742.

Zanetti-Domingues, L.C., Martin-Fernandez, M.L., Needham S.R, D.J Rolfe and D.T. Clarke. A systematic investigation of differential effects of cell culture substrates on the extent of artifacts in single-molecule tracking. PLoS ONE(2012) 7(9): e45655.

doi:10.1371/journal.pone.0045655.

Martiniere, I. Lavagi, G. Nageswaran, D.J Rolfe, L. Maneta-Peyret, D-T. Luu, S. W Botchway, S.E D Webb, S. Mongrand, C. Maurel, M.L Martin-Fernandez, J. Kleine-Vehn, J. Friml, P. Moreau, and J. Runions. The cell wall constrains lateral diffusion of plant plasma-membrane proteins. PNAS. (2012) pnas.1202040109

C.J. Tynan, David T. Clarke, Benjamin C. Coles, M.L. Martin-Fernandez and S.E. D. Webb. Multicolour Single Molecule Imaging with Near Infra-red Dyes. PLoS ONE. (2012) 7(4): e36265. doi:10.1371/journal.pone.0036265

S.E.D. Webb, D.J. Rolfe, B.C. Coles, R. Wareham and M.L. Martin-Fernandez. (2012) Multicolour single molecule imaging in cells using a supercontinuum source. Biomed. Opt. (2012) Exp. Vol. 3, No. 3: 400-406.

M.L. Martin-Fernandez. Human Epidermal Growth Factor Receptor (HER1) aligned on the plasma Membrane Adopts Key Features of Drosophila EGFR Asymmetry. Biochem. Soc. Trans.(2012) 40(1):184-188

S. K. Roberts, C.J. Tynan, M. Winn, and M.L. Martin-Fernandez. Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy. Biochem. Soc. Trans. (2012) 40(1):189-194.

D.J. Rolfe, C.I. McLachlan, M. Hirsch, S.R. Needham, C.J. Tynan, S. E. D. Webb, M. L. Martin-Fernandez and M.l.P. Hobson. Automated multidimensional single molecule fluorescence microscopy feature detection and tracking. Eur. Biophys. J.(2011) 40:1167–1186.

​D.T. Clarke, S.W. Botchway, B.C. Coles, S. R. Needham, S.K. Roberts, D.J. Rolfe, C.J. Tynan, A.D. Ward, S.E.D. Webb, R. Yadav, L. Zanetti-Domingues, and M.L. Martin-Fernandez. Optics clustered to output unique solutions: A multi-laser facility for combined single molecule and ensemble microscopy. Rev. Sci. Ins. (2011) 82, Article Number: 093705.

G. Vizcay Barrena, S.E.D. Webb, M.L. Martin-Fernandez, and Z.A. Wilson. Subcellular and single-molecule imaging of plant fluorescent proteins using total internal reflection fluorescence microscopy (TIRFM) J. Exp. Bot.  (2011) 62 (15): 5419-5428.

F. Hussain, M. Parsons, M. Snippe, C. Farmer, P. E. Morton, M.L. Martin-Fernandez and George Santis. (2011). CAR Modulates E-Cadherin Dynamics in the Presence of Adenovirus Type 5. PLoS ONE  (2011) 6 (8):  Article Number: e23056

C.J. Tynan, S.K. Roberts, D.J. Rolfe, D.T. Clarke, H.H. Loeffler, J. Kästner, M.D. Winn P.J. Parker and M.L. Martin-Fernandez. Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of drosophila EGFR asymmetry. Mol. Cell Biol.(2011) 31(11):2241-2252.

S. E. D. Webb, C.J. Tynan, L. Zanetti-Domingues, B.C. Coles, S.K. Roberts, D.J. Rolfe, S. R. Needham, M. Hirsch, D.T. Clarke, and M.L. Martin-Fernandez. Simultaneous, multicolour single molecule imaging of the entire ErbB receptor family in live cells. Eur. Biophys. J. with Biophys. Lett.(2011) 40(1): 154.

Askari J.A., Tynan C.J., Webb S.E.D., Martin-Fernandez M.L., Ballestrem C., Humphries M.J. Focal adhesions are sites of integrin extension. J. Cell Biology(2010) 188(6):891-903.

Ismail T.M., Zhang S., Fernig D.G., Gross S., Martin-Fernandez M.L., See V., Tozawa K, Tynan C.J., Tynan, C.J., Wang G.Z., Wilkinson M.C., Rudland P.S. and Barraclough R. (2010). Self-association of Calcium-binding Protein S100A4 and Metastasis. J. Biol. Chem.(2010) 285(2):914-922.

Kastner J., Loeffler H.H., Roberts S.K., Martin-Fernandez M.L., and Winn M.D. (2009). Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics. J. Structural Biology(2009) 167(2):117-128.

S.E.D. Webb, D.J. Rolfe, S.R. Needham, S. K. Roberts, D.T. Clarke, C.I. McLachlan, M.P. Hobson and M.L. Martin-Fernandez. Simultaneous widefield single molecule orientation and FRET microscopy in cells. Optics Express(2008) 16(25): 20258-20265.

S.E.D. Webb, S. K. Roberts, S.R. Needham, C.J. Tynan, D.J. Rolfe, M.D. Winn, R. Barraclough, D.T. Clarke, and M.L. Martin-Fernandez. Single molecule imaging and FLIM show different structures for high and low-affinity EGFRs in A431 cells. Biophysics Journal (2008) 94:803-819.

Stephen E. D. Webb, Selene K. Roberts, Sarah R. Needham, Daniel J. Rolfe, Chris J. Tynan, and M.L. Martin-Fernandez. Epidermal growth factor signalling studied using multidimensional single molecule fluorescence microscopy. Proc. SPIE (2007) 6441, 64410E.

S.E.D. Webb, S.R. Needham, S.K. Roberts, and M.L. Martin-Fernandez. Multidimensional single molecule imaging in live cells using total internal reflection fluorescence microscopy. Optics Letters  (2006) 15;31(14):2157-9.

S. Zhang, G. Wang, D.G. Fernig, P.S. Rudland, S.E.D. Webb, R. Barraclough, and M.L. Martin Fernandez. Binding of Metastasis-associated S100A4 Protein to Non-muscle Myosin Heavy Chain in vivo Visualized by Fluorescence Resonance Energy Transfer Microscopy. European Biophysics Journal with Biophysics Letters(2005) 34 (1): 19-27.

G. Wang, S. Zhang, D.G. Fernig, M.L. Martin Fernandez, P.S. Rudland, and R. Barraclough. Mutually Antagonistic Actions of S100A4 and S100A1 on Normal and Metastatic Phenotypes.  Oncogene (2005) 24 (8): 1445-1454.

M.L. Martin-Fernandez, S.V. Longshaw, I. Kirby, G. Santis, M.J. Tobin, D.T. Clarke, and G.R. Jones. Adenovirus Type 5 Entry and Disassembly Followed in Living Cells by FRET, Fluorescence Anisotropy, and FLIM. Biophysics Journal (2004) 87:1316-1327.

Moritz W, Yoshinobu T, Finger F, F, Krause S, Martin-Fernandez M.L., Schoning MJ. High resolution LAPS using amorphous silicon as the semiconductor material. Sensor Actuat B-Chem (2004) (1-2): 436-441.

G. Wang, S. Zhang, D.G. Fernig, D. Spiller, M.L. Martin Fernandez, H. Zhang, Y. Ding, Z. Rao, P.S. Rudland, and R. Barraclough. Heterodimerisation and heterodimeric interfaces of S100A1 and S100P. Biochemical Journal(2004) 382: 375-383.

M.L. Martin-Fernandez, M.J. Tobin, S.V. Jones, D.T. Clarke, and G.R. Jones. Preformed Oligomeric EGF Receptors Undergo an Ectodomain Structure Change during Signalling.  Biophysics Journal (2002) 82: 2415–2427.

Clarke, D.T., Seddon, E.A.; Quinn, F.M.; Clarke, J.A. Tobin, M.J., Martin-Fernandez, M.L., and Jones, G.R. 4GLS - A fourth generation light source that for the biomedical scientist is more than a laser and more than a storage ring. Biomedical Applications of Ultrafast and Free-Electron Lasers(2002) 4633: 233-242.

Martin-Fernandez, M.L., Clarke, D.T., Tobin, M.J., and Jones, G.R. Real-time studies of the interactions between epidermal growth factor and its receptor during endocytic trafficking. Cell. Mol. Biol.(2000) 46, 1103-1112.

Clarke, D.T., Bowler, M., Felll, B., Flaherty, J., Grant, A., Jones, G., Martin-Fernandez, M.L., Shaw, D., Todd, B., Wallace, B. and Towns-Andrews, E.. A high aperture beamline for vacuum ultraviolet circular dichroism on the SRS. Synchrotron Radiation News, (2000) 13 (2). pp. 21-27. ISSN 0894-0886. DOI: 10.1080/08940880008261066 ·

Martin-Fernandez, M.L., Tobin, M.J., Clarke, D.T., Gregory, C.M., and Jones, G.R. Sub-nanosecond polarised microfluorimetry in the time domain: An instrument for studying receptor trafficking in live cells. Rev. Sci. Instrum. (1998) 69, 540-543.

Tobin, M.J., Martin-Fernandez, M.L., and Jones, G.R. A facility for confocal imaging and microvolume fluorescence lifetime spectroscopy at the SRS. Pages 24-30

.doi/abs/10.1080/08940889808260938.  Synchrotron Radiation News(1998) 11

Martin-Fernandez, M.L., Tobin, M.J., Clarke, D.T., Gregory, C.M., and Jones, G.R. A high sensitivity time-resolved microfluorimeter for real-time cell biology. Rev. Scientific Instruments(1996) 67, 3716-3721.

Martin-Fernandez, M.L., Bordas, J., Diakun, G., Harries, J., Lowy, J., Mant, G.R., Svensson, A., Towns-Andrews, E. Time-resolved X-ray-diffraction studies of myosin head movements in live frog sartorius muscle during isometric and isotonic contractions. J. Muscle Res. Cell Mot. (1994) 15, 319-348.

Martin-Fernandez M.L., Diakun, G.P., Diaz F.G., Harries J.E., Lewis R.A., Lowy, Mant G., Towns-Andrews E. and Bordas, J. (1994).  X-ray-diffraction evidence for a specific actomyosin complex in live isometrically contracting frog sartorius muscle. Synchrotron. Rad. Biosciences(1994) 435-442.

Bordas, J., Diakun, G.P., Diaz, F.G., Harries, J.E., Lewis, R.A., Lowy, J., Mant, G.R., Martin-Fernandez, M.L., and Towns-Andrews E. Two-dimensional time-resolved X-ray-diffraction studies of live isometrically contracting frog sartorius muscle. J. Muscle Res. Cell Mot. (1993)14, 311-324.

Harries, J.E., Martin-Fernandez, M.L., Diakun, G.P., Mant, G.R., Bordas, J. A comparative-study of the supramolecular structure of frog sartorius and dorsal semitendinosus muscle. J. Structural Biology(1991) 106, 264-271.

J. Bordas, G.P. Diakun, J.E. Harries, R.A. Lewis, G.R. Mant, M.L. Martin-Fernandez, E. Towns-Andrews. Two-dimensional time resolved X-ray diffraction of muscle: Recent results. Advances in Biophysics. (1991) Volume 27, Pages 15-33

​Worgan, J.S., Lewis, R., Fore, N.S., Sumner, I.L., Berry, A, Parker, B., Dannunzio, F., Martin-Fernandez, M.L., Towns-Andrews, E., Harries, J.E., Mant, G.R., Diakun, G., Bordas, J. The application of multiwire x-ray-detectors to experiments using synchrotron radiation. Nuc Ins. & Met. Phys. Res.(1990) 291, 447-454.

Patents

  1. ​Patent awarded: S.E.D. Webb and M.L. Martin-Fernandez. (2009). Single Molecule Fluorescence Measurement (No. GB0707433.9). (50%)
     
  2. Filed Patent: Application UK 1507202.8 - Receptor Tyrosine Kinase Biomarkers (2015)

  3. Filed Patent: Application UK 1704275.5 – Cryo Super-resolution microscopy (2017)

​Chapters in books

M.L. Martin-Fernandez, David T. Clarke, Sarah R. Needham, Selene K. Roberts, Daniel J. Rolfe, Chris J. Tynan, Stephen E.D. Webb and Martyn Winn. (2011). Investigating the conformation of membrane proteins in cells via single molecule microscopy. Molecular Imaging. ISBN 979-953-307-076-5.

D.T. Clarke, S.E.D. Webb, D.J. Rolfe, M.D. Winn and M.L. Martin-Fernandez. (2011). Single molecule fluorescence imaging of molecular interactions in mammalian cells In “Microscopy: Science, Technology, Applications and Education". Edt. A. Mendez-Vilas & J. Diaz.

N.J. Gay, M. Symmons, M.L. Martin-Fernandez, G. Jones. Structure and Stabilisation of Self-assembling Peptide Filaments. Self-assembling Peptide Systems in Biology, Medicine and Engineering'. Kluwer Academic Publishers, pp 113-125.

Nicholson, J., Martin-Fernandez, M.L., Reynolds, C., Wood, C. & Baldwin, J. (2006). Future opportunities for chromatin structure-function research on the proposed UK Fourth Generation Light Source (4GLS). In 'Chromatin Structure and Function'. Edt J. Nicholson and C. Wood: 141-152. (12 pages, 20%).

R.D.Perrins, M.L.Martin-Fernandez, M.J.Tobin, C.W.Wharton & R.A.Meldrum (2005) Real-time imaging of photo-controlled DNA polymerisation. Mutation Research, Fundamental & Molecular Mechanisms of Mutagenesis 577, Supp1, 573. (20%)

​Conference ​papers

Needham, S.R, Zanetti-Domingues, L.C., Arkhipov, A., Mysore, V., Korovesis, D., Roberts, S.K., Tynan, C. J., Rolfe, D. J., Hirsch, M., Lajevardipour, A., Clayton, A.H.A., Parker, P.J., Shan, Y.E. Shaw, D. and Martin-Fernandez, M. L. (2017). Oligomerization of the Epidermal Growth Factor Receptor Organizes Kinase-Active Dimers into Competent Signaling Platforms. Biophysical J. 112. 26a-27a. 10.1016/j.bpj.2016.11.180.

Webb, S.E.D., Needham, S.R., Roberts, S.K., Martin-Fernandez, M.L. Nanoscale EGFR separations in cells using fluorophore localisation confidence intervals. 9th European-Biophysical-Societies-Association Congress, Volume: 42 (2013).

Tynan, C.J., Roberts, S.K., Martin-Fernandez, M.L. Human-EGFR aligned on the plasma membrane adopts key features of Drosophila-EGFR asymmetry (2011). Biochemical Society, V2, (2011).

Askari, J. A., Tynan, C. J., Webb, S. E., Martin-Fernandez, M. L., Ballestrem, C., Humphries, M. J. (2010). Imaging integrin alpha 5 beta 1 conformation on adherent cells' International J. Exp. Path. 91 (6)

​Other publications

M.L.Martin-Fernandez. STFC Fascination; Healthcare Special Issue 9. (2012)

C.J. Tynan, D.J. Rolfe, D.T. Clarke, M.D. Winn and M.L. Martin-Fernandez. Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of drosophila EGFR asymmetry. Central Laser Facility Annual Report 2011-2012

D.T. Clarke, S.R. Needham, D.J. Rolfe and M.L. Martin-Fernandez. (2011) Measuring nanodistances in cells. Imaging & Microscopy 13: 40-42.

D.T. Clarke, S.R. Needham, D.J. Rolfe and M.L. Martin-Fernandez. (2011) Measuring nanodistances in cells. G.I.T. Laboratory Journal 15: 19-21.

S.E.D. Webb, D.J. Rolfe, B.C. Coles, R. Wareham and M.L. Martin-Fernandez. Multicolour single molecule imaging in cells using a supercontinuum source. Central Laser Facility Annual Report 2011-2012.

D.T. Clarke, M.L. Martin-Fernandez and M. Towrie. The Lasers for Science Facility in the Research Complex at Harwell. Central Laser Facility Annual Report 2010-2011.

S.E.D. Webb, G. Vizcay Barrena, M.L. Martin-Fernandez, and Z.A. Wilson. Subcellular and single-molecule imaging of plant fluorescent proteins using total internal reflection fluorescence microscopy (TIRFM). Central Laser Facility Annual Report 2010-2011.

M.L. Martin-Fernandez and S. Nelson. From outer space to improve cancer care. STFC highlights 2009-2010. In press. (~ 2 pages, 50%).

M.L. Martin-Fernandez, D.T. Clarke and S.E.D. Webb.  An OCTOPUS in the Research Complex. Central Laser Facility Annual Report 2009-2010. (4, 50%).

M.L. Martin-Fernandez. Supra-molecular rules in signalling networks: A single molecule comparative study in cells and tissues. Central Laser Facility Annual Report 2009-2010. In Press (100%).

H.H. Loeffler, J. Kaesner, M.D. Winn, M.L. Martin-Fernandez, and S.K. Roberts. Larger and longe: atomistic and coarse-grained s​imulations of the Epidermal Growth Factor Receptor. CSE annual report 2008, pp.16-17 (2, 25%).

D. T. Clarke, S. W. Botchway, M. L. Martin-Fernandez, S. R. Needham, A. W. Parker, D. A. Rolfe, S. K. Roberts, C. J. Tynan and S. E. D. Webb. The Octopus imaging cluster: a new facility for the LSF. Central Laser Facility Annual Report 2008-2009, pp. 149-152. (3, 60%).

J. A. Askari, C. Ballestrem, C. J. Tynan, S. E. D. Webb and M. L. Martin-Fernandez Fluorescence lifetime imaging microscopy (FLIM) to visualise conformational changes in integrin a5b1. Central Laser Facility Annual Report 2008-2009, pp. 145-147. (3, 60%).

M.L. Martin-Fernandez. Lab-in-a-cell: a stepping-stone between the lab and the patient. Synchrotron Radiation Department Annual Report 2006-2007, pp. 34-35. (2 pages, 100%).

M.L. Martin-Fernandez and S.E.D. Webb. Probing receptor conformation to unlock cell proliferation. Synchrotron Radiation Department Annual Report Highlights 2004-2005, pp. 24-25. (2 pages, 80%).

M.L .Martin-Fernandez and S.E.D. Webb. Stopping cancer in its tracks. CCLRC Annual Report 2004-2005, pp 26-27. (2 pages, 50%). This article was mentioned by the Lord Sainsbury (Under Secretary of State, Science and Innovations Minister 1998-2006) in a letter to the then CLRC director, John Wood as an example of high impact.

M.L. Martin-Fernandez. More to a sneeze than meets the eye. Synchrotron Radiation Department Annual Report Highlights 2002-2003, (2 pages, 100%).

M.L. Martin-Fernandez. More to a sneeze than meets the eye. CCLRC Annual Report 2002-2003, pp. 16-17. (2 pages, 100%).

M.L. Martin-Fernandez, Tobin, M.J., Jones, S.V., Jones, G.R., and Botchway, S.W. (2002). Following Adenovirus entry in living cells by fluorescence lifetime microscopy. Annual Report of the Central Laser Facility 2001-2002 (2 pages, 80%).

Clarke, D.T., Bowler, M.A., Fell, B.F., Flaherty, J.V., Grant, A.F., Jones, G.R., Martin-Fernandez, M.L., Shaw, D.A., Todd, B., Wallace, B.A., and Towns-Andrews E.  (2000). A High Aperture Beamline for Vacuum Ultraviolet Circular Dichroism on the SRS. SRN 13(2): 21-27. (10%) 

Tobin, M.J., Martin-Fernandez, M.L., and Jones, G.R. (1998). A facility for confocal imaging and microvolume fluorescence lifetime spectroscopy at the SRS. SRN 11(4): 24-30. (7 pages, 20%) ​

Martin-Fernandez, M.L. Cell signalling directs protein traffic. Scientific Highlights SRD annual report, 1996-1997, pp 24-25. (2 pages, 100%).

 

 


Contact: Bateman, Benji (STFC,RAL,CLF)